If you're not at all familiar with the Dune series, then you might want to familiarize yourself with at least the first book before reading this one. (Or you could watch the movies "Dune" and "Children of Dune") Although "Hunters of Dune" takes place in a much more distant future than the original Dune story, many of the characters are gholas, or clones, of the original characters in Frank Herbert's series.
This book was written by Frank's son, Brian Herbert and co-written by Kevin J. Anderson. However, it is supposed to be based off of an original outline written by Frank and locked away in a safe deposit box. Sounds a little too "Holy Grail" to me, but who cares? It's a good story, regardless of who wrote it.
Like I was saying, a lot of the characters and historical events referenced in "Hunters" took place in the previous books, but you can follow along perfectly well with only a base knowledge of the Dune world. The story does a good job of clarifying background information, without too much time spent backtracking. I noted a pleasant lack of "previously on Gossip Girl..." type reiteration.
Hunters of Dune takes place after the escape of the Reverend Mother Sheena, the ghola of Mentat Duncan Idaho and several other refugees from the new rule of the Mother Commander Murbella on Chapterhouse.
While onboard their escape ship, these refugees stumble upon the opportunity to create gholas of many of Dune history's most famous characters. Meanwhile, Mother Commander Murbella is working to form a new alliance between the viscious Honored Matres and the powerful Bene Gesserite, and alliance than many, including Sheeana and tribes of rebel Honored Matres consider a horrific alliance and afront to their beliefs.
As Murbella's New Sisterhood grows, all will find that they must either join or prepare to fight, as she builds her army and prepares to fight the unknown Enemy that she knows is coming to annihilate the entire Old Empire. The book ends as the Enemy launches it's attack and is continued in "Sandworms of Dune."
It's a good read, though it starts out somewhat slow. Once it picks up, it's bloody, intriguing and fast-paced. The entire Dune series is really a must-read for any sci-fi fan.